Orexin receptor activation visualised by intramolecular FRET
نویسندگان
چکیده
Background: Orexin receptors are potential targets for the treatment of narcolepsy and insomnia. Results: Intramolecular FRET sensor forms of these receptors were functional and able to report the kinetics of agonist-mediated activation. Conclusions: The 33 amino acid peptide orexin A activates the receptors slowly. Significance: Such sensors provide a unique means to explore the kinetics of receptor activation.
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